Results 41 to 50 of about 29,271 (183)

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Calix[4]arene Design for Enhanced Carbon Capture via Topological Learning

Chemistry – A European Journal, EarlyView.
ABSTRACT Solid direct air capture (S‐DAC) technologies have the potential to remove pre‐existing CO2 from the atmosphere by taking advantage of hydrophobic materials that will retain CO2 through physisorption and separating it from the abundant water molecules. Calix[n]arenes are highly tunable and versatile complexes with inherent hydrophobic cavities,
Jeffrey A. Laub, Konstantinos D. Vogiatzis   +1 more
wiley   +1 more source

Unlocking Heterobimetallic Architectures in a Symmetric PNNP Ligand Environment

Chemistry – A European Journal, EarlyView.
A symmetric PNNP ligand enables the modular assembly of heterobimetallic ZnRu and CoRu complexes from a mononuclear Ru(II) precursor. Ligand deprotonation triggers dearomatization and contraction of the metal–metal distance. Combined DFT and QTAIM analyses reveal metallophilic interaction in CoRu but not in ZnRu, highlighting controllable geometric and
Stanislav Melnikov, Menne W. P. Verkooijen, Jop Verduin, Martin Lutz, Daniël L. J. Broere   +4 more
wiley   +1 more source

Si─Si Bonding in an Unsupported N‐Heterocyclic Silylene Dimer Stabilized by an Iminophosphorane‐Based Scorpionate Ligand Versus Head‐to‐Tail Coordination in the Sn and Pb Tetrylenes

Chemistry – A European Journal, EarlyView.
A new iminophosphorane‐based scorpionate ligand enabled the characterization of a head‐to‐head silylene dimer with unsupported Si─Si bonding, whereas the tetrylene species of Sn and Pb afforded head‐to‐tail coordination polymers in the solid state. ABSTRACT N,N‐chelating ligands disfavor element–element bonding in heavier alkene analogs of group 13 and
Huanhuan Dong, Rochelle Ferns, Luke W. Giles, Lea Fohlmeister, Connor Bourne, Samuel R. Lawrence, Aidan P. McKay, Alexandra M. Z. Slawin, David B. Cordes, Tanja van Mourik, Andreas Stasch   +10 more
wiley   +1 more source

Invariant Measure and Universality of the 2D Yang–Mills Langevin Dynamic

Communications on Pure and Applied Mathematics, EarlyView.
ABSTRACT We prove that the Yang–Mills (YM) measure for the trivial principal bundle over the two‐dimensional torus, with any connected, compact structure group, is invariant for the associated renormalised Langevin dynamic. Our argument relies on a combination of regularity structures, lattice gauge‐fixing and Bourgain's method for invariant measures ...
Ilya Chevyrev, Hao Shen
wiley   +1 more source

Nonlocal problems with singular nonlinearity

, 2016
We investigate existence and uniqueness of solutions for a class of nonlinear nonlocal problems involving the fractional $p$-Laplacian operator and singular nonlinearities.Comment: 20 ...
Canino, Annamaria, Montoro, Luigi, Sciunzi, Berardino, Squassina, Marco   +3 more
core  

Phosphoryl Halogen and Hydrogen Bonding Controls the Solid‐State Structures of Aryl Halide‐Containing Phosphonates

European Journal of Inorganic Chemistry, EarlyView.
Intramolecular (RO)2PO→Halogen interaction versus intermolecular (RO)2PO···HOH hydrogen bonds. Although the O···I distance is shorter than the sum of the van der Waals radii of the atoms involved, there is no covalency involved in this interaction.
David Mross, Paweł Horeglad, Bastian Grabe, Wolf Hiller, Vito Lippolis, Massimiliano Arca, Klaus Jurkschat   +6 more
wiley   +1 more source

A Crystalline Ylide‐Stabilized Stibenium Cation

European Journal of Inorganic Chemistry, EarlyView.
The isolation of a stibenium cation stabilized by two thiophosphinoyl‐tethered ylide groups is reported. The cation is accessible via salt metathesis of the metalated ylide with SbCl3 and features CSb single bonds, with lone pairs remaining localized at the ylidic carbon atoms.
Daniel Knyszek, Margarita Shishkova, Leif Kelling, Henning Steinert, Viktoria H. Gessner   +4 more
wiley   +1 more source

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source