Results 131 to 140 of about 5,769,861 (240)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Food, Financial Crises, and Complex Derivatives: A Tale of High Stakes Innovation and Diversification [PDF]
The 2008 food price crisis was an integral part of the financial crisis. In fact, the food price crisis was the second crisis in a chain of events that began in 2007 with the mortgage crisis, and culminated in the worst financial crisis since the Great ...
Songwe, Vera
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Constraining U.S. and EU Domestic Support in Agriculture: The October 2005 WTO Proposals [PDF]
In October 2005 the USA, EU, and G-20 submitted proposals on domestic support in the WTO agriculture negotiations. We consider the de minimis rules and allowances, project future (2014) distorting support for the USA and the EU-15, calculate the ...
Brink, Lars
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
More than a dozen countries, including Brazil, China, India, Japan, and Korea, have been intervening in the foreign exchange market to prevent their currencies from appreciating.
John Williamson, William R. Cline
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
High reduction of ozone and particulate matter during the 2016 G-20 summit in Hangzhou by forced emission controls of industry and traffic. [PDF]
Environ Chem Lett, 2017 Li P +12 more
europepmc +1 more source
A Fresh Look at Global Governance: Exploring Objective Criteria for Representation [PDF]
The geopolitical world of the 21st century is very different than that of the post– World War II era. In this new world order, what constitutes a system of global governance?
Enrique Rueda-Sabater +2 more
core +1 more source