Results 51 to 60 of about 3,298,579 (267)

Nifurtimox plus eflornithine for late-stage sleeping sickness in Uganda: A case series [PDF]

, 2007
Background: We report efficacy and safety outcomes from a prospective case series of 31 late-stage T. b. gambiense sleeping sickness (Human African Trypanosomiasis, HAT) patients treated with a combination of nifurtimox and eflornithine (N+ E) in Yumbe ...
Thomas, F, Legros, Dominique, Francesco Checchi, Patrice Piola, Thomas Florence, Ayikoru Harriet, Gerardo Priotto, Piola, P, Ayikoru, H, Piola, Patrice, Ayikoru, Harriet, Checchi Francesco, Legros, D, Thomas, Florence, Priotto Gerardo, Checchi, F, Priotto, Gerardo, Florence Thomas, Priotto, G, Checchi, Francesco, Legros Dominique, Dominique Legros, Harriet Ayikoru, Piola Patrice   +23 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Late-season data

, 2016
Late-season data used in analyses of end of season variation in ectoparasites, endoparasites, male mobility, badge size, and ...
Erik Wapstra (314066), Mats Olsson (351776), Lindsay, Willow R., Bengt Silverin (169024), Willow R. Lindsay (203598), Silverin, Bengt, Olsson, Mats, Wapstra, Erik   +7 more
core   +1 more source

Auto Fish: Leveraging AI for fish species identification in natural habitats

مجلة النهرين للعلوم الهندسية
Identifying fish species in natural aquatic environments remains challenging due to changing light conditions, turbid water, and complex underwater scenes.
Neha Bora, Rajendra S. Chaudhari, Monika P. Surse, Rajendra C. Patil, Pradyumna Mulchand Bora   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of a protocol complexity tool: a framework designed to stimulate discussion and simplify study design

BMC Medical Research Methodology
Background Over the last decade, the pharmaceutical industry has witnessed longer, more complex, and expensive clinical trials. This complexity contributes to delays in clinical trial implementation, execution, monitoring, recruitment, data cleaning, and
Bartholomeus J.A. Willigers, Agata E Wiesiolek, Bruce Potter, Alina Pszczółkowska, Cecilia Kristensson , Veronica Presz , Gabriela Luporini Saraiva, Ioannis Psallidas   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

V Congress of Polish Society of Neuroendocrinology 21–22 September, 2018 Kraków — Late abstracts

, 2018
V Congress of Polish Society of Neuroendocrinology 21–22 September, 2018 Kraków — Late ...
Abstracts, Late
core