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Nuclear regulatory legislation, 104th Congress, Volume 1, No. 4

, 1997
This document is the first of two volumes compiling statutes and material pertaining to nuclear regulatory legislation through the 104th Congress, 2nd Session. It is intended for use as a U.S.

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A bifunctional carborane-quinazoline combines tumor growth inhibition and boron delivery for boron neutron capture therapy in melanoma and non-small cell lung cancer models

Frontiers in Chemical Biology
BackgroundBoron neutron capture therapy (BNCT) is a binary therapeutic modality based on the nuclear reaction between boron-10 (10B) and low-energy neutrons, generating high-linear-energy-transfer (LET) α-particles (4He) and recoiling lithium-7 (7Li ...
María Alejandra Dagrosa, María Alejandra Dagrosa, María Alejandra Dagrosa, Marina Carpano, Antonella Pastini, Antonella Pastini, Estanislao Pavlik, Andrés Bechis, Andrés Bechis, María Silvina Olivera, Pablo Vallecorsa, Belén Dávila, Belén Dávila, Luciano Parodi, Esther Yardena Salem, María Sol Espain, María Sol Espain, Agustina Mariana Portu, Agustina Mariana Portu, Laura Todaro, Laura Todaro, Alejandro Urtreger, Alejandro Urtreger, Pablo Menendez, Hugo Cerecetto, Hugo Cerecetto, Hugo Cerecetto, Marcos Couto, Marcos Couto   +28 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Nuclear Development Corporation of America Report 2562-1

, 1958
Report presenting the results of an investigation of the technical feasibility and economic attractiveness of a 200 MWₑ power reactor using natural uranium fuel, a heavy water moderator, and a high pressure and temperature stream coolant.
East Central Nuclear Group
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Cobaltabis(Dicarbollide) [o-COSAN]⁻ for Boron Neutron Capture Therapy of Head and Neck Cancer: Biodistribution and Irradiation Studies in an Experimental Oral Cancer Model

Pharmaceuticals
Background: Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy that combines preferential boron accumulation in tumors and neutron irradiation.
Mónica A. Palmieri, Andrea Monti Hughes, Verónica A. Trivillin, Marcela A. Garabalino, Paula S. Ramos, Silvia I. Thorp, Paula Curotto, Emiliano C. C. Pozzi, Miquel Nuez Martínez, Francesc Teixidor, Clara Viñas, Amanda E. Schwint   +11 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The Reproducibility of Nuclear Morphometric Measurements in Invasive Breast Carcinoma

Analytical Cellular Pathology, 1997
The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer.
Pauliina Kronqvist, Teijo Kuopio, Yrjö Collan, Csaba Horvath, Ülle Tamm   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Controlling the atom. The beginnings of nuclear regulation 1946--1962 [PDF]

, 1997
This book traces the early history of nuclear power regulation in the US. It focuses on the Atomic Energy Commission (AEC), the federal agency that until 1975 was primarily responsible for planning and carrying out programs to protect public health and ...
Walker, J. S., Mazuzan, G. T.
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