Results 51 to 60 of about 3,474,405 (252)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PET/CT with 18-fluor-fluorodeoxyglucose in the follow-up of the cutaneous malignant melanoma
Saúde & Tecnologia, 2015 Background – Cutaneous malignant melanoma (CMM) is one of the most lethal malignancies and the follow-up involves, in addition to clinical examination and analysis of tumor markers, several imaging methods such as the Positron Emission Tomography ...
Sofia Batanete +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
NRC - regulator of nuclear safety
, 1997 The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants.
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Using Largest Lyapunov Exponent to Confirm the Intrinsic Stability of Boiling Water Reactors
Nuclear Engineering and Technology, 2016 The aim of this paper is the study of instability state of boiling water reactors with a method based in largest Lyapunov exponents (LLEs). Detecting the presence of chaos in a dynamical system is an important problem that is solved by measuring the LLE.
Carlos J. Gavilán-Moreno +1 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nuclear Regulatory Commission Report NUREG-0084
, 1977 The proposed project: Pursuant to the Atomic Energy Act, as amended, the U.S. Nuclear Regulatory Commission's regulations in Title 10, Code of Federal Regulations, an application with an accompanying Environmental Report, was filed by Northeast Utilities
U.S. Nuclear Regulatory Commission. Office of Nuclear Reactor Regulation.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Memoria 2021 Área Sanitaria de Ferrol
, 2023 [GLG] Resumo da actividade global de descrición detallada da actividade realizada polos distintos servizos da Área Sanitaria de Ferrol, ao longo do ano 2021, tanto no hospital como nos centros de saúde.[ES] Resumen de la actividad global de descripción ...
core +1 more source