Results 21 to 30 of about 3,875 (160)

Une occupation rurale du second âge du Fer et du Haut-Empire sur le site de l’aérodrome à Chartres (Eure-et-Loir)

Revue Archéologique du Centre de la France, 2023
A rural settlement dating from the Second Iron Age and the Roman period has been unearthed on the airfield site in Chartres.During the first phase of its occupation, dated to the Final Hallstatt or Early La Tène period, it comprised just a few structures,
Bruno Lecomte, Jonathan Simon
doaj  

Metalografia unor piese din fier descoperite Ia Siret in anul 1994

Arheologia Moldovei, 2016
Includes a summary in French La Métallographie de Quelques Objets en fer Découverts à Siret en 1994 On a déterminé, par analyse métallographique, la structure d’un groupe de pièces en fer, découvertes à  l’occasion des fouilles archéologiques ...
Maria Geba, Adrian Vusatiuc
doaj   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Innovations et métallurgies en Méditerranée occidentale (XIIIe–XVe siècles)

Anuario de Estudios Medievales, 2011
[fr] Après avoir défi ni l’innovation technique au Moyen Âge et ses rapports à l’industrie, cet article en étudie les caractéristiques dans les domaines de la métallurgie du fer et de l’argent (plomb et cuivre argentifères) du XIIIe au XVe siècle, en ...
Catherine Verna
doaj   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Architecture antique entre âge du Fer et époque impériale en Provence : les piliers du site de Château-Bas à Vernègues

Gallia, 2013
The site of Château-Bas (Vernègues, Bouches-du-Rhône), famous above all for its Augustan Roman temple, has yielded a set of pillars decorated either with writhing snakes or with straight rods. As yet there are no known parallels to such pillars.
Sandrine Agusta-Boularot, Raphaël Golosetti   +1 more
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

‘They Even Have the Capacity, but the Places Aren't Prepared to Receive Them’: Community Environment and Participation of Autistic Children in a Family‐Engaged Research Analysis

Autism Research, EarlyView.
ABSTRACT To examine the associations between community environmental barriers and support and the participation of autistic children, and to interpret these findings from the perspective of caregivers engaged as research partners. This cross‐sectional observational study employed a mixed‐methods design.
Léia Cordeiro de Oliveira, Cid André Fidelis de Paula Gomes, Gustavo Pietracatelli Janizello, Wallace Pereira Silva, Alice Soper, Monika Novak‐Pavlic, Olaf Kraus de Camargo, Soraia Micaela Silva   +7 more
wiley   +1 more source

Pointes de flèche en fer forgé du Moyen Âge : recherche expérimentale sur leur technique de fabrication

Revue Archéologique de l’Est, 2007
Medieval blacksmiths were able to produce different shaped wrought iron arrowheads with great dexterity using only simple techniques and their know-how. Our research on the history of archery (Centre expérimental de Préhistoire alsacienne, 1982-1998, and
Jean Sainty, Jean Marche
doaj   +1 more source