Results 31 to 40 of about 3,875 (160)

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Un établissement du début du premier âge du Fer en Eure-et-Loir : Sours, Les Ouches

Revue Archéologique du Centre de la France, 2011
The excavation of the site of Ouches at Sours (28) has enabled the updating of an important settlement from the early Neolithic and the discovery, in the northern part of the site, of several structures datable to the beginning of the Iron Age (Hallstatt 
Frédéric Dupont, Bruno Lecomte, Jérémie Liagre, Julie Rivière, Jonathan Simon   +4 more
doaj  

Quercetin‐zinc coordination polymer coated CaCO3 nanoparticles potentiate radiotherapy through reprogramming tumor immunosuppression

BMEMat, EarlyView.
Synthesis of QZCaCO3‐PEG to synergistically enhance the immunogenicity of radiotherapy through concurrent Zn2+‐induced cancer cell pyroptosis and Que‐mediated hypoxia amelioration through sequentially suppressing TGF‐β secretion and ECM deposition. Abstract Radiotherapy has demonstrated broad applications in treating solid tumors, but the hostile tumor
Chunjie Wang, Hengze Ding, Yu Hao, Honglin An, Ziliang Dong, Minming Chen, Yujie Zhu, Quguang Li, Bin Huang, Liangzhu Feng   +9 more
wiley   +1 more source

Les puits du second âge du Fer à Toulouse. Dix ans de recherches préventives : problématiques, méthodes, résultats et perspectives

Archéopages, 2012
Excavations in advance of development in the area of Saint-Roch/Saint-Agne in Toulouse have led to a reconsideration of its Later Iron Age shafts. The assemblages they contained, and hence the shafts themselves, has long been interpreted as funerary or ...
Christophe Requi
doaj   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Cercetările arheologice din aşezarea precucuteniană de la Chipereşti-Iaşi

Arheologia Moldovei, 2022
Dans ce travail on présente les résultats des recherches archéologiques obtenues à la suite d’un sondage effectué dans le village Chiperești, Țuțora, dép.
Constantin Iconomu, Nicolae Ciudin
doaj   +1 more source

Mixed‐Impurity Co‐Poisoning of NH3‐SCR Catalysts: Poisoning Mechanisms, Antagonistic Effects, and Anti‐Inactivation Strategies

EcoEnergy, EarlyView.
This review summarizes the synergistic effects of mixed impurities on ammonia‐selective catalytic reduction (NH3‐SCR) catalysts, including the poisoning mechanism of the catalyst caused by mixed impurities, the antagonistic effects between the impurities, and the research on the anti‐poisoning strategies for the catalyst in recent years.
Hongyan Xue, Manas Pal, Zhaoteng Xue, Dongsen Mao   +3 more
wiley   +1 more source

Air pollution exposure during training impairs performance in Thoroughbred racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Ambient air pollution contributes substantially to human morbidity and mortality, and athletes are recognised as a particularly vulnerable group. However, little is known about the impact of air pollution on equine athletes. Objectives To explore the relationship between air pollution exposure during the pre‐competition training ...
Danielle Scott, Kathryn Seabaugh, Linda Kim, Sheryl Magzamen, Colleen Duncan   +4 more
wiley   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Dynamique de peuplement dans les marges orientales de l’Adamaoua

Les Nouvelles de l’Archéologie, 2010
Lorsque nous avons élargi en 2005 nos travaux sur la néolithisation, l’apparition et le développement de la métallurgie du fer à toute l’extrémité orientale de l’Adamaoua, l’identification des communautés de la préhistoire récente à partir des ensembles ...
Étienne Zangato
doaj   +1 more source