Results 31 to 40 of about 431,968 (200)

Nicole et les grands ensembles

open access: yesStrenae, 2018
Publiée entre 1969 et 1978 par la maison d’édition communiste La Farandole, la série des « Nicole » d’Andrée Clair et Bernadette Després est une série originale dans le paysage des albums pour enfants.
Christophe Meunier
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Rémanence de Madame Bovary dans l’édition illustrée

open access: yesFlaubert: Revue Critique et Génétique, 2014
This article focuses on the illustrated editions of Madame Bovary. After Flaubert’s death these editions were popular and multiplied until the end of the 1850’s. They represent a testimony of the novel’s reception by illustrators.
Bruno Gallice
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

La conscience du monument en Suisse. De l’appropriation à la mnémotechnologie

open access: yesIn Situ, 2014
The Swiss Art History Society is a private association of public interest that carries out standard institutional mandates. It can boast of a longstanding tradition while being extremely innovative.
Nicole Bauermeister
doaj   +1 more source

Écritures théâtrales françaises et dramaturgies d’Afrique et des diasporas : une aventure ambiguë?

open access: yesPercées, 2020
Cet article revient sur les réseaux d’émergence des écritures d’Afrique subsaharienne francophone et d’Outre-Mer. Il pose la question de leur place dans le paysage des écritures françaises d’aujourd'hui. En effet, cette place ne va pas de soi alors qu’en
Pénélope Dechaufour
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi   +13 more
wiley   +1 more source

Reflexiones en torno a una edición digital del Liber regum (o Libro de las generaciones y linajes de los reyes)

open access: yesE-Spania, 2013
Dans cet article, l’auteur présente quelques réflexions suscitées par la préparation d’une édition numérique du Liber regum (ou Libro de las generaciones y linajes de los reyes).
Hélène Thieulin-Pardo
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

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