Results 91 to 100 of about 4,791,418 (250)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

La recherche participative entre commande évaluative et visée émancipatrice : le cas d’une recherche-intervention portant sur un dispositif de prévention des violences sexuelles

open access: yesLa Revue LEeE, 2019
La présente contribution rend compte d’une recherche-intervention conduite à la demande d’un Centre de Ressources pour les Intervenants auprès des Auteurs de Violences Sexuelles (CRIAVS).
Dominique Broussal
doaj   +1 more source

Renforcement concerté des capacités des particuliers : phase 3 de l'évaluation stratégique du renforcement des capacités du CRDI

open access: yes, 2007
Version anglaise disponible dans la Bibliothèque numérique du CRDI: Working together to strengthen skills in individuals : IDRC's strategic evaluation of capacity development, phase
CRDI. Section de l'évaluation
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Renforcement concerté des capacités des organismes : phase 3 de l'évaluation stratégique du renforcement des capacités du CRDI

open access: yes, 2007
Version anglaise disponible dans la Bibliothèque numérique du CRDI: Working together to strengthen skills in organizations : IDRC's strategic evaluation of capacity development, phase
CRDI. Section de l'évaluation
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Lundi 13 mai 2019. ÉVALUATION GÉNÉRALE. Effets de l'ÉVALUATION #2

open access: yes, 2019
Journée d'études "Évaluation générale. Effets de l’évaluation # 2"  Lundi 13 mai, 9h30-18h Université Paris 8, Salle des thèses Espace Deleuze (Bât. A 1er étage) Deuxième journée d'études autour du projet "Évaluation générale.
Nancy Murzilli
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Le test de compréhension de l’IRonie et des Requêtes Indirectes – version courte (IRRI-C) : développement, validité de contenu et données normatives préliminaires.

open access: yesGlossa
Contexte : Suite à un traumatisme crânio-cérébral ou une lésion hémisphérique droite, de nombreux patients présentent des difficultés à comprendre le langage non littéral.
Natacha Cordonier   +2 more
doaj   +1 more source

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