Results 111 to 120 of about 4,791,418 (250)
Rapport annuel sur l'évaluation 1999
, 1999 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Annual corporate evaluation report ...
CRDI. Section de l'évaluation
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Préparation des objectifs de programme
, 2004 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Preparing program ...
CRDI. Section de l'évaluation
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Constatations en bref de l'examen externe du programme Pauvreté urbaine et environnement
, 2009 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Findings brief : external review of the Urban Poverty and Environment ProgramCe texte présente les principales constatations du rapport intitulé Final Report to IDRC: Urban Poverty and
CRDI. Section de l'évaluation
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Répertoire des rapports d’évaluation
, 2012 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Evaluation ...
CRDI. Section de l'évaluation
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Constatations en bref de l'examen externe des Partenariats canadiens
, 2010 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Findings brief : external review of the Canadian Partnerships ProgramCe texte présente les principales constatations du rapport intitulé Canadian Partnerships (CP) Program External ...
CRDI. Section de l'évaluation
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source