Results 181 to 190 of about 4,791,418 (250)

« Politiques régionales et développement numérique : compte rendu de la thèse de Charlotte Ullmann »

Netcom, 2007
Philippe Vidal
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Fissure Sealant Provision for High Caries Risk Children Within the Community Dental Service. [PDF]

Int J Paediatr Dent
Shand B, Madden K, Kaur B, Davies S.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA): protocol for an embedded mixed-methods process evaluation. [PDF]

BJA Open
Dunn C, Connolly B, Blackwood B, Silversides JA, Emerson LM, SINFONIA investigators.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Reliability of Human Evaluation of Large Language Models in Health Care Settings: Scoping Review. [PDF]

J Med Internet Res
Yang E, Ko S, Woo H.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Hospital readmissions of frail older individuals: the challenge of anticipating end-of-life care

Frontiers in Medicine
Fabien Visade, Fabien Visade, Chloé Prod'homme, Jean-Baptiste Beuscart   +3 more
doaj   +1 more source

Detection-Guided ROI-Constrained Diffusion for Weakly Supervised White Blood Cell Segmentation: A Retrospective Internal and External Dataset Evaluation. [PDF]

J Clin Med
Bamwenda J, Özerdem MS, Ayyildiz O, Akpolat V, Akpolat İ.   +4 more
europepmc   +1 more source