Results 161 to 170 of about 4,501,314 (250)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
What Does it Take for an R&D Tax Incentive Policy to Be Effective? [PDF]
While in 1996, 12 OECD countries offered R&D tax incentives, in 2008 this number increased to 21. Most countries have opted for level-based instead of incremental R&D tax incentives.
Boris Lokshin, Pierre Mohnen
core
The magic of first impressions: Do facial displays on online platforms affect users' offline conversion rate? [PDF]
PLoS OneZhang X, Li Q, Han C, Huang X.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Compte-rendu détaillé en textes, photos et dessins de la journée d'etudes du 25 mars 2019
, 2019 Compte rendu établi par Nancy Murzilli, Valérie Pihet et Bérengère Voisin avec les notes manuscrites de Natacha Guiller et les vidéos d'Amélie Ferrand et de Serena Cello La journée d’études du 25 mars 2019 « Evaluation générale. L’Agence de notation #1 »,
Nancy Murzilli
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Serious Game Aimed at Assessing Executive Planning Skills in Children With Autism: Cross-Sectional Design and Formative Evaluation of ShopAutiPlan. [PDF]
JMIR Serious GamesShamhan ANM +3 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Évaluation des programmes d'études
, 1988 Titre de la couv.: Évaluation des programmes d ...
Québec (Province). Direction du développement de l'évaluation
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Références bibliographiques du dossier « Palmarès et classements en éducation »
Revue Internationale d’Éducation de Sèvres, 2010 Bernadette Plumelle
doaj +1 more source