Results 191 to 200 of about 4,466,005 (254)

Tuning and clinical application of large language models in Traditional Chinese Medicine: scoping review. [PDF]

Chin Med
Han C, Yang G, Li H, Zhu L, Feng M.
europepmc   +1 more source

Agroecology in Madagascar: from the plant to the landscape [PDF]

, 2019
Autfray, Patrice, Dusserre, Julie, Naudin, Krishna, Penot, Eric, Raboin, Louis-Marie, Raharison, Tahina, Rakotoarisoa, Jacqueline, Ramanantsoanirina, Alain, Randrianjafizanaka, Meva Tahiry, Rasolofo, Laingo Irintso, Raveloson, Harinjaka, Razafimahatratra, Mamy, Salgado, Paulo, Scopel, Eric, Sester, Mathilde, Vom Brocke, Kirsten   +15 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Age and sex differences in paediatric tuberculosis care for child contacts. [PDF]

J Glob Health
Boretsky A, Amanullah F, Hussain H, Malik AA, Brooks MB.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Co-STARS: a feasibility evaluation of a co-produced mental health literacy training package to reduce mental health inequities for Black young people in underserved communities - study protocol for a randomised controlled trial with an external pilot, process evaluation and economic analysis. [PDF]

BMJ Open
Kumarendran B, Cherrington E, Bandyopadhyay S, Crowe F, Machaczek KK, Brown L, Campbell N, Jordan G, Pope MA, Antonović M, Taylor M, W N, Mahamud A, Chandan JS, Griffiths SL, Co-STARS youth co-production group.   +15 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Evaluation Models for Undergraduate Nursing Clinical Skills: A Scoping Review Protocol.

JMIR Res Protoc
Metersky K, Lin T, Lam T, Al-Hamad A, Romaniuk D.   +4 more
europepmc   +1 more source

A Dynamic Hybrid Weighting Framework for Teaching Effectiveness Evaluation in Multi-Criteria Decision-Making: Integrating Interval-Valued Intuitionistic Fuzzy AHP and Entropy Triggering. [PDF]

Entropy (Basel)
Lu C, Zhang Y.
europepmc   +1 more source