Results 21 to 30 of about 155,290 (193)
Constatations en bref de l'examen externe du programme Écosystèmes et santé humaine
, 2009 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Findings brief : external review of the Ecosystem Approaches to Human Health ProgramCe texte présente les principales constatations du rapport intitulé External Review of the IDRC ...
CRDI. Section de l'évaluation
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Présentation des rapports d'évaluation au CRDI
, 2012 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Formatting evaluation reports at ...
CRDI. Section de l'évaluation
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Rédaction du mandat d'évaluation
, 2004 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Writing Terms of Reference (ToRs) for an ...
CRDI. Section de l'évaluation
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Constatations en bref de l'examen externe du programme Pan Asie
, 2010 Version anglaise disponible dans la Bibliothèque numérique du CRDI: External review of the Pan Asia Networking ProgramCe texte présente les principales constatations des rapports intitulés Pan Asia Networking (PAN) Prospectus Review 2006-2011, préparé ...
CRDI. Section de l'évaluation
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Planification de l'évaluation dans les initiatives de programme
, 2004 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Evaluation planning in program ...
CRDI. Section de l'évaluation
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source