Results 31 to 40 of about 155,290 (193)

Examen externe du programme Recherche pour la lutte mondiale contre le tabac (RMCT)

open access: yes, 2010
Version anglaise disponible dans la Bibliothèque numérique du CRDI: External review of the Research for International Tobacco Control ProgramCe texte présente les principales constatations des rapports intitulés Rapport du programme RMCT visant la ...
CRDI. Section de l'évaluation
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Le savoir-évaluer comme politique éducative : Vers une évaluation plus profonde

open access: yes, 2011
L’évaluation vécue dans les écoles américaines a changé de rôle. De l’évaluation à dimension humaine, nous sommes passés, dans de nombreux pays, à une évaluation de performance standardisée et quantitative dont la fonction est politique, que cet essai ...
Tochon, François Victor
core   +1 more source

La Technologie éducative : les nouveaux choix /

open access: yes, 1985
Cet ouvrage donne un compte-rendu des communications présentées au 4e Colloque du Conseil interuniversitaire des professeurs en technologie ...
Conseil interuniversitaire des professeurs en technologie éducative   +1 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

open access: yesMolecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara   +10 more
wiley   +1 more source

Démarche du CRDI en matière d'évaluation

open access: yes, 2007
Version anglaise disponible dans la Bibliothèque numérique du CRDI: IDRC's approach to ...
CRDI. Section de l'évaluation
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Renforcement concerté des capacités : phase 3 de l'évaluation stratégique des activités de renforcement des capacités du CRDI; élaboration du cadre d'évaluation

open access: yes, 2007
Version anglaise disponible dans la Bibliothèque numérique du CRDI: Working together to strengthen skills : IDRC's strategic evaluation of capacity development, phase 3; developing the ...
CRDI. Section de l'évaluation
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Choix de l’évaluateur ou de l’équipe d'évaluation

open access: yes, 2012
Version anglaise disponible dans la Bibliothèque numérique du CRDI: Selecting an evaluation consultant or ...
CRDI. Section de l'évaluation
core  

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