Results 171 to 180 of about 71,600,009 (285)

Préparation des objectifs de programme

, 2004
Version anglaise disponible dans la Bibliothèque numérique du CRDI: Preparing program ...
CRDI. Section de l'évaluation
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Escola de la Marina Mercant de la Mediterrania. Informes: Sant Must. Junta Económica-Administrativa Asunt Vich.

, 1937
Informe del Delegat de la Generalitat de Catalunya a L' Escola de la Marina Mercant de la Mediterrània, informes de la Junta Economico-Administrativa per l' assumpte Vich ...
Delegat de la Generalitat de Catalunya
core  

Improving nurses' alarm-management performance with a behavioral reminder. [PDF]

Rev Esc Enferm USP
Topçu S, Sari MK, Yilmaz MŞ, Ürkmez DÖ.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Interpretable LLM-Based Detection of Loose Associations Using Synthetic Speech Data in Early Psychosis. [PDF]

Schizophr Bull
Gutiérrez E, Quesada C, DeFraites E, Harper DJ, Mandavia AD.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Med-CoReasoner: Reducing Language Disparities in Medical Reasoning via Language-Informed Co-Reasoning. [PDF]

Proc Conf Assoc Comput Linguist Meet
Gao F, Tong ST, Sohn J, Huang J, Jiang J, Xia D, Ittichaiwong P, Veerakanjana K, Kim H, Chen Q, Taylor EM, Kobayashi K, Aizawa A, Li I.   +13 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Validation of the new Sequential Organ Failure Assessment 2 score in community-acquired pneumonia. [PDF]

ERJ Open Res
González-Jiménez P, Latorre A, Piqueras M, Mengot N, Hervás D, Menéndez R, Méndez R.   +6 more
europepmc   +1 more source