Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
CT Attenuation Thresholds for Grading Hepatic Steatosis in Adults with Overweight or Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]
Diagnostics (Basel)Góngora-Chan P +11 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2006 Version anglaise disponible dans la Bibliothèque numérique du CRDI: Filing rPCRs in ...
CRDI. Section de l'évaluation
core
Improving Diagnostic Sensitivity in Imbalanced Oral Cancer Image Classification: A Comparative Study of CNN and Transformer Architectures. [PDF]
Cancers (Basel)Ormeño-Arriagada P +6 more
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
LES VILLES ET LA CRISE, la situation financière des municipalités urbaines dans dix pays en période de récession (1978-1985) [PDF]
Le milieu des années 1970 a marqué un tournant dans l'évolution des politiques locales. La crise économique a provoqué une raréfaction des ressources et un accroissement des dépenses sociales, elle a obligé les municipalités à s'adapter et à innover. Une
Jean-Yves Nevers
core
Development and Validation of a Computer Vision-Based Artificial Intelligence System (FenoParasite) for the Microscopic Detection of <i>Ascaris lumbricoides</i> and <i>Giardia lamblia</i> in Stool Samples. [PDF]
Trop Med Infect DisHueda-Zavaleta M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source