Results 91 to 100 of about 2,885 (104)
Advanced Science, EarlyView.A sustainable high‐performance epoxy vitrimer (F9T1) was developed via a rigid‐flexible integrated design using rigid and flexible bio‐based epoxy monomers. F9T1 features superior mechanical property, char‐forming ability, fire safety, chemical degradability and recyclability due to its rigid‐flexible network with abundant dynamic disulfide and ester ...
Yong Guo +11 more
wiley +1 more source
Mapping Charge Interactions in Intrinsically Disordered Proteins
Advanced Science, EarlyView.This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips +14 more
wiley +1 more source
Advanced Science, EarlyView.Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu +8 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu +7 more
wiley +1 more source
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, EarlyView.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism
Advanced Science, EarlyView.Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards +8 more
wiley +1 more source
Advanced Science, EarlyView.ROS‐ and NIR light‐cascade activatable NIR‐II AIE theranostic probe (TT‐DHIn) is developed by integration of dihydroindole skeleton with oxidative dehydrogenation reaction mechanism and AIE skeleton with a twisted configuration. Upon ROS in the tumor microenvironment and NIR light activation, TT‐DHIn can achieve dual‐model imaging‐guided precise tumor ...
Xiaohui Chen +12 more
wiley +1 more source
Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges
Advanced Science, EarlyView.This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li +7 more
wiley +1 more source
Advanced Science, EarlyView.By exploiting the strong nonlinear optical response and controllable molecular ordering of ferroelectric nematic liquid crystals (FNLCs), these materials can serve as tunable sources of polarization‐entangled photons. Adjusting the sample geometry or applying an external electric field enables continuous control of the entanglement degree, advancing ...
Sara Klopčič +3 more
wiley +1 more source
Advanced Science, EarlyView.A solar‐powered nanoelectrokinetic filtration system enables high‐flux removal of ultrafine contaminants without relying on nanoscale pores or pressure‐driven membranes, offering a sustainable solution for the off‐grid water purification. Abstract The removal of ultrafine suspended solids from water remains a critical challenge due to the tradeoffs ...
Woonjae Choi +4 more
wiley +1 more source