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Results 131 to 140 of about 8,492,007 (269)

, 2017
Intensification of systemic chemotherapy with incinclusionof high doses methotrexate (MTX) has contributed to the improvement of event-free survival in children with acute lymphoblastic leukemia (ALL). Despite this benefit, this agent might cause serious
Ð§Ð¾Ð½ÐµÑÐºÐ°-ÐˆÐ¾Ð²Ð°Ð½Ð¾Ð²Ð° (Choneska-Jovanova), Ð‘Ð¸Ð»Ñ˜Ð°Ð½Ð° (Biljana) +6 more
core +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source

, 2016
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Ð¸Ð½Ñ„Ð¾Ñ€Ð¼Ð°Ñ‚Ð¸ÐºÐ°, ÐœÐ•Ð”Ð˜Ð¡ -
core +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

B ¯ → D ¯ D $$ \overline{B}\to \overline{D}D $$ decays and the extraction of f d /f u at hadron colliders

Journal of High Energy Physics
We perform a detailed model-independent phenomenological analysis of B ¯ → D ¯ D $$ \overline{B}\to \overline{D}D $$ decays. Employing an SU(3) F analysis including symmetry-breaking contributions together with a conservative power counting for various ...
Jonathan Davies, Martin Jung, Stefan Schacht +2 more
doaj +1 more source

Novell ÑÐµ Ð·Ð´Ñ€ÑƒÐ¶ÑƒÐ²Ð° ÑÐ¾ lntel [PDF]

, 2016
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Ð¸Ð½Ñ„Ð¾Ñ€Ð¼Ð°Ñ‚Ð¸ÐºÐ°, ÐœÐ•Ð”Ð˜Ð¡ -
core +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source

Adobe Ð³Ð¸ Ð·Ð´Ñ€ÑƒÐ¶ÑƒÐ²Ð° ÑÐ¸Ð»Ð¸Ñ‚Ðµ ÑÐ¾ Netscape [PDF]

, 2016
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Ð¸Ð½Ñ„Ð¾Ñ€Ð¼Ð°Ñ‚Ð¸ÐºÐ°, ÐœÐ•Ð”Ð˜Ð¡ -
core +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source

ÐŸÐžÐ’ÐÐ–ÐÐ˜Ð¢Ð• ÐÐÐ¡Ð¢ÐÐÐ˜ Ð’Ðž 1995 [PDF]

, 2016
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Ð¸Ð½Ñ„Ð¾Ñ€Ð¼Ð°Ñ‚Ð¸ÐºÐ°, ÐœÐ•Ð”Ð˜Ð¡ -
core +2 more sources

astrophysics
hadron-hadron scattering experiments
b physics

7. clean energy