Results 151 to 160 of about 9,272,993 (249)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Impact of Different π-Bridges on the Photovoltaic Performance of A-D-D'-D-A Small Molecule-Based Donors. [PDF]

Molecules
Yang L, Wu Y, Murugan P, Liu P, Peng Y, Qiu Z, Li Z, Yu C, Liu S.   +8 more
europepmc   +1 more source

Фрактури на долен вратен 'рбет, заден или преден приÑтап

, 2016
ИзваР...
Тодоров (Todorov), Илија (Ilija)
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

CD квалитети и аудио Ñо новиот Sony-евиотнов MD диÑк

, 2016
изваР...
информатика, МЕДИС -
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Long-Term Performance and Bulk-Isotope Effects in Methane Clumped-Isotope Measurements Using a 253 Ultra HR-IRMS. [PDF]

Rapid Commun Mass Spectrom
Zhang N, Gilbert A, Nakagawa M, Surma J, Meissner JGC, Mohn J, Bernasconi SM, Ueno Y, Yoshida N.   +8 more
europepmc   +1 more source

Продолжува здружувањето на големите

, 2016
изваР...
информатика, МЕДИС -
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source