Results 131 to 140 of about 8,672,710 (262)

ТокÑични ефекти предизвикани од хемотерапија Ñо виÑоки дози метотрекÑат кај деца Ñо акутна лимфоблаÑтна леукемија [PDF]

, 2017
Intensification of systemic chemotherapy with incinclusionof high doses methotrexate (MTX) has contributed to the improvement of event-free survival in children with acute lymphoblastic leukemia (ALL). Despite this benefit, this agent might cause serious
ЧонеÑка-Јованова (Choneska-Jovanova), Билјана (Biljana), ÐлабаковÑка (Alabakovska), Соња (Sonja), ÐнтевÑка Трајкова (Antevska Trajkova), Зорица (Zorica), Мартинова (Martionva), Ката (Kata), Кочева (Kocheva), Светлана (Svetlana), КузевÑка Манева (Kuzevska Maneva), КоÑтандина (Kostandina), ЈовановÑка (Jovanovska), ÐлекÑандра (Ðleksandra)   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

IBM разви диÑк од 1 GB за преноÑните компјутери [PDF]

, 2016
изваР...
информатика, МЕДИС -
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Virtual Reality Visualiser - беÑплатно на World Wide Web [PDF]

, 2016
изваР...
информатика, МЕДИС -
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On Extended d-D Kappa Distribution

Axioms
The thermal Doppler broadening of spectral profiles for particle populations in the absence or presence of potential fields can be described by kappa distributions.
Arak M. Mathai, Hans J. Haubold
doaj   +1 more source

Сложувалка [PDF]

, 2016
изваР...
ПетковÑки, Ðиколче-
core   +1 more source

The d'--d--d' vertical triad is less discriminating than the a'--a--a' vertical triad in the antiparallel coiled-coil dimer motif. [PDF]

J Am Chem Soc, 2012
Steinkruger JD, Bartlett GJ, Hadley EB, Fay L, Woolfson DN, Gellman SH.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source