Results 171 to 180 of about 8,475,584 (303)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

ÐÐÐÐРРÐÐÐÐÐÐТÐÐЬÐÐÐ¥ (Ðg, Сo) ÐÐС(ЦÐТРÐТÐ)ÐÐРÐÐÐÐТÐÐ (СТÐÐÐТÐÐ) ÐÐ ÐÐÐÐÐ ÐâЯÐÐÐÐÐРТÐÐУСУ

, 2015
М. В. Матюшкіна
openalex   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function. [PDF]

Rev Esc Enferm USP
Zhao S, Zheng W, Long G, Liang G.
europepmc   +1 more source

ÐФÐÐТÐÐÐÐСТЬ ÐÐТÐÐÐÐÐТÐЧÐÐÐ ÐÐРÐÐЦÐÐ ÐÐСÐÐРÐÐÐÐТÐÐЬÐÐÐÐ ÐÐФУÐÐÐÐÐ ÐШÐÐÐЧÐÐ-ÐÐÐРÐТÐЧÐÐÐÐ ÐÐРÐÐÐСÐÐÐРÐÐУ

, 2015
Г. С. Сатурська, Ю. І. Бондаренко, О. В. Денефіль, Н. Я. Потіха, С. М. Чарнош, В. Є. Пелих, К. Є. Юріїв   +6 more
openalex   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

ÐÐСÐÐÐÐÐÐÐЯ ÐÐРÐШÐÐРРÐСÐÐÐÐÐÐ¥ ÐÐСТРÐÐТÐÐ Ð ÐÐТÐЮ СТÐÐРÐÐÐЯ СУÐÐÐÐТÐРÐÐÐ ÐÐЯ ÐÐÐУÐÐÐÐЯ ÐÐÐ¥ÐÐРЮÐÐÐЬ ÐÐРÐÐÐÐХУРÐÐÐÐ ÐÐÐÐÐÐ

, 2014
В. І. Гриценко, О. А. Рубан   +1 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Tagelda n Kuku d tqerrabin d lǧerrat tinmettiyin i d-teǧǧa

Revue d'Histoire Méditerranéenne
Deg umagrad-a, nemmeslay-d ɣef yiwet n tgelda i yesɛan azal meqqren deg umezruy atrar n Lezzayer s umata ladɣa amezruy n tmurt n Leqbayel, tagi d tageda n Kuku i d-ibanen deg useggas 1511, seld tuṭṭfa n temdint n Bgayet s ɣur Spenyul deg useggas 1510 ...
BENCHIKHE Ali
doaj  

ÐÐÒРУÐТУÐÐÐÐЯ ÐÐâÐÐТÐÐÐÐСТРСÐÐÐСТРÐÐÐÐРТÐСТÐÐÐÐÐ ÐСÐÐТУ ÐÐЯ ÐЦÐÐЮÐÐÐÐЯ ÐÐÐÐЬ Ð ÐÐФÐÐЦÐÐÐÐÐ¥ Ð¥ÐÐРÐÐ

, 2013
В. П. Марценюк, П. Р. Сельський   +1 more
openalex   +2 more sources