Results 271 to 280 of about 8,213,460 (300)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Relationship between group B Streptococcal rectovaginal colonization and Vitamin D deficiency in pregnant women. [PDF]

BMC Pregnancy Childbirth
Mehta S, Simeunovic S, Catalano N.
europepmc   +1 more source

Миграционные ÑвойÑтва нитратов как индикатор Ñ„ÑƒÐ½ÐºÑ†Ð¸Ð¾Ð½Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ñ‡Ð² Ñтепной зоны КазахÑтана

, 2012
T. Ryspekov
openalex  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The prevalence of vitamin D deficiency and insufficiency in calcium oxalate stone formers in Ontario, Canada, and the impact of vitamin D supplementation. [PDF]

Can Urol Assoc J
Basulto-Martinez M, Khandwala Z, Alotaibi T, Ierides S, Bjazevic J, van Uum S, Clemens KK, Razvi H.   +7 more
europepmc   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Dysregulated vitamin D signaling in Hashimoto's thyroiditis: an integrated transcriptomic study in a Korean cohort. [PDF]

Front Endocrinol (Lausanne)
Lim DW, Jeong HJ, Lee JS, Choi MS, Fang S, Wang JH, Kim H, Kim SM.   +7 more
europepmc   +1 more source

Ð”ÐµÐ³Ð¸Ð´Ñ€Ð°Ñ‚Ð°Ñ†Ð¸Ñ Ð±Ð¸Ð¾Ñтанола в Ñтилен на окÑидных катализаторах

, 2013
К. Dossumov, Dina Churina, Ðœ. Telbayeva, K. Kalikhanov   +3 more
openalex   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

The Distribution of Nitric Oxide-Synthesizing Neurons and Soluble Guanylate Cyclase in Relation to Dopaminergic Systems in the Pigeon Brain. [PDF]

J Comp Neurol
Steinemer A, Ziegler M, Haselhuhn K, Güntürkün O, Rook N.   +4 more
europepmc   +1 more source