Results 101 to 110 of about 609 (189)

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Preferential C-nociceptor stimulation facilitates peripheral axon reflex flare, but not secondary mechanical hyperalgesia. [PDF]

Front Pain Res (Lausanne)
Daneffel L, Rukwied R, Schmelz M, Ruppen W, Schneider T.   +4 more
europepmc   +1 more source

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, 2016
Александр Чернавин
openalex   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

ÐСÐÐÐÐÐÐСТРУРÐÐÐÐÐЯ ÐÐРÐРУ Ð¥ÐÐРÐÐ¥ ÐРХРÐÐÐЧÐÐÐ ÐÐÐÐТÐТ С (ÑÑÑаÑÐ½Ñ ÑÑÐ²Ð»ÐµÐ½Ð½Ñ Ð¿Ñо меÑанÑзми ÑозвиÑкÑ, клÑнÑÑÐ½Ñ ÑпоÑÑеÑеженнÑ)

, 2013
Ю.Ю. Рябоконь, В.О. Туманський, Т.Г. Светличенко   +2 more
openalex   +2 more sources

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, EarlyView.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

ÐÐ°Ð´Ð·Ð¾Ñ Ð·Ð° иÑполнением законов оÑганами, оÑÑÑеÑÑвлÑÑÑими дознание и пÑедваÑиÑелÑное ÑледÑÑвие

, 2016
Валерия Валерьевна Малинина
openalex   +1 more source

Steep discounting of delayed monetary and food rewards in obesity: a meta-analysis

Psychological Medicine, 2016
M. Amlung, Tashia Petker, J. Jackson, I. Balodis, James MacKillop   +4 more
semanticscholar   +1 more source