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Results 111 to 120 of about 6,426,241 (257)

, 2017
Acute appendicitis is very common acute surgical condition in childhood that requires quick and safe treatment with least possible complications.
Ð¡Ð¸Ð¼ÐµÐ¾Ð½Ð¾Ð², Ð Ð¸ÑÑ‚Ð¾
core

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner +2 more
wiley +1 more source

, 2017
Two sucker babies with fibrosa cystic have been presented: in one of them the disease was severe with the lethal outcome, while the other baby could be successfully treated.
Ð¡Ð¿Ð¸Ñ€Ð¾Ð²ÑÐºÐ¸ (Spirovski), Ð—Ð¾Ñ€Ð°Ð½ (Zoran) +2 more
core

Systematics and Faunistics of Neotropical Grapholitini, 1: Dichrorampha Guenée, 1845 (Lepidoptera: Tortricidae)

SHILAP, 2012
Se describen dieciocho especies de Dichrorampha neotropicales (D. obliqua Razowski & Becker, sp. n., D. brusquaea Razowski & Becker, sp. n., D. mnesisocia Razowski & Becker, sp. n., D. atomosa Razowski & Becker, sp. n., D. limae Razowski & Becker, sp. n.,
J. Razowski, V. O. Becker
doaj

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source

, 2017
Epidemiological data indicates that thyroid carcinoma (TC) is the most frequent endocrinological tumors, participating with around 1% from all malignomas.
ÐœÐ°ÐºÐ°Ð·Ð»Ð¸ÐµÐ²Ð° (Makazlieva), Ð¢Ð°ÑšÐ° (Tanja) +3 more
core

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source

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