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Results 61 to 70 of about 5,871,885 (248)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source

ÐÐšÐžÐÐžÐœÐ˜Ð§Ð•Ð¡ÐšÐ˜Ð• Ð Ð«Ð§ÐÐ“Ð˜ ÐœÐ£ÐÐ˜Ð¦Ð˜ÐŸÐÐ›Ð¬ÐÐžÐ™ ÐŸÐžÐ›Ð˜Ð¢Ð˜ÐšÐ˜ Ð’ Ð¡Ð¤Ð•Ð Ð• ÐžÐ¥Ð ÐÐÐ« ÐÐ¢ÐœÐžÐ¡Ð¤Ð•Ð ÐÐžÐ“Ðž Ð’ÐžÐ—Ð”Ð£Ð¥Ð ÐÐ ÐŸÐ Ð˜ÐœÐ•Ð Ð• Ð“ÐžÐ ÐžÐ”Ð Ð›Ð¬Ð’ÐžÐ’Ð

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source

ÐžÐ¡ÐžÐ‘Ð•ÐÐÐžÐ¡Ð¢Ð˜ Ð ÐÐ¡Ð§Ð•Ð¢Ð Ð¡Ð¢ÐžÐ˜ÐœÐžÐ¡Ð¢Ð˜ Ð—Ð•ÐœÐ•Ð›Ð¬ÐÐžÐ“Ðž Ð£Ð§ÐÐ¡Ð¢ÐšÐ Ð”Ð›Ð¯ Ð¡Ð¢Ð ÐžÐ˜Ð¢Ð•Ð›Ð¬Ð¡Ð¢Ð’Ð Ð˜ ÐžÐ‘Ð¡Ð›Ð£Ð–Ð˜Ð’ÐÐÐ˜Ð¯ Ð–Ð˜Ð›ÐžÐ“Ðž Ð”ÐžÐœÐ .

Supermembranes and domain walls in N $$ \mathcal{N} $$ = 1, D = 4 SYM

Journal of High Energy Physics, 2019
We construct a manifestly supersymmetric and kappa-symmetry invariant worldvolume action describing the coupling of a dynamical membrane to an N $$ \mathcal{N} $$ = 1, D = 4 SU(N ) super-Yang-Mills multiplet.
Igor Bandos, Stefano Lanza, Dmitri Sorokin +2 more
doaj +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source

Ticraḍ, gar usemres d wazal n yizamulen i d-mmalent

Ussnan
This contribution aims to describe the practice of tattooing in some Amazigh regions. It tries to list the different techniques, the actors plus the means used to succeed in this practice which has a high value in the society.
Ourida AISSOU
doaj

ÐœÐ•ÐÐ•Ð”Ð–ÐœÐ•ÐÐ¢ ÐšÐ£Ð›Ð¬Ð¢Ð£Ð Ð« Ð’ ÐœÐÐ›ÐžÐœ Ð‘Ð˜Ð—ÐÐ•Ð¡Ð• Ð Ð•Ð¡ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ˜ ÐœÐžÐ›Ð”ÐžÐ’Ð

N-ACETYL-β-D-GLUCOSAMINIDASE OF VIBRIO CHOLERAE

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Study N-acetyl-β-D-glucosaminidase (chitobiase) (EC 3.2.1.30) in strains of Vibrio cholerae of O1/non-O1 serogroups of various origin, that is a component of chitinolytic complex taking into account object of isolation and epidemiologic significance
O. V. Duvanova +3 more
doaj +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source

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