Results 211 to 220 of about 6,329,447 (296)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

РазÑабоÑка полиÑики пÑÐ¾Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ Ð¾ÑганизаÑии

, 2017
Пенкин, Павел
openalex   +1 more source

IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism. [PDF]

Diabetes
Lu X, Bai N, Lyu J, Sun J, Su Y, Ye Y, Hu T, Liu T, Li W, Li X, Ma X, Yang Y, Bao Y.   +12 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ÐкÑпеÑименÑалÑне доÑлÑÐ´Ð¶ÐµÐ½Ð½Ñ Ð¼ÐµÑÐ¾Ð´Ñ Ð·Ð°Ð±ÐµÐ·Ð¿ÐµÑÐµÐ½Ð½Ñ ÑÑÑйкоÑÑÑ ÐºÑÑÑиÑÐ¾Ð²Ð¸Ñ Ð¿ÑоÑоколÑв кванÑÐ¾Ð²Ð¾Ñ ÐºÑипÑогÑаÑÑÑ

, 2016
Гнатюк, Сергій Олександрович; Національний авіаційний університет, Жмурко, Тетяна Олександрівна; Національний авіаційний університет, Кінзерявий, Василь Миколайович; Національний авіаційний університет   +2 more
openalex   +1 more source

Current Status of Implantable Cardioverter-Defibrillators (ICDs)/Cardiac Resynchronization Therapy With Defibrillators (CRT-Ds) for Primary Prevention of Sudden Cardiac Death. [PDF]

J Arrhythm
Yokoshiki H, Watanabe M, Mitsuhashi T, Shimizu A.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ÐÑо меÑÐµÐ¶Ñ RFWKIDEA16-8, RFWKIDEA16-4, RFWKIDEA16-2 Ñа RFWKIDEA16-1, ÑÑвоÑÐµÐ½Ñ Ð½Ð° оÑÐ½Ð¾Ð²Ñ Ð¼ÐµÑÐµÐ¶Ñ IDEA16-8

, 2014
Туйчиев, Гулом Нумонович; Национальный университет Узбекистана им. Мирзо Улугбека
openalex   +1 more source

Predicting Oral Food Challenge Outcomes in Cow's Milk Protein Allergy: The Crucial Role of Bos d 8 and Component-Resolved Diagnostics: A Narrative Review. [PDF]

Int J Mol Sci
Balas W, Tylewicz A, Gromek W, Sobota W, Sybilski A, Majsiak E.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source