Results 21 to 30 of about 6,074,365 (251)
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Sodium [N,N′-ethylenebis(d-penicillaminato)]indate(III) tetrahydrate
IUCrData, 2019 The asymmetric unit of the title compound {systematic name: sodium [2-({2-[(1-carboxylato-2-methyl-2-sulfanidylpropyl)amino]ethyl}amino)-3-methyl-3-sulfanidylbutanoato-κ4S,N,N′,S′]indate(III) tetrahydrate}, Na[In(C12H20N2O4S2)]·4H2O, contains four indate(
Nobuto Yoshinari, Takumi Konno
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
4-(Benzo[d]thiazol-2-yl)-N,N-dimethylaniline
IUCrData, 2016 The whole molecule of the title compound, C15H14N2S, is approximately planar, with an r.m.s. deviation of 0.0382 Å from the best-fit mean plane through all 18 non-H atoms.
Yi-Wen Tang +4 more
doaj +1 more source
A D-N alternating algorithm for exterior 3-D problem with ellipsoidal artificial boundary
AIMS Mathematics, 2022 In this study, based on a general ellipsoidal artificial boundary, we present a Dirichlet-Neumann (D-N) alternating algorithm for exterior three dimensional (3-D) Poisson problem.
Xuqiong Luo
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Pervyj opyt perevoda Evangelija ot Ioanna na udmurtskij jazyk: grafiko-orfografičeskij analiz [Abstract. Graphical and Spelling Analysis of the Handwritten Gospel of St. John in Udmurt]; pp. 276-283 [PDF]
Linguistica Uralica, 2012 The article deals with the features of spelling of the handwritten Gospel of St. John in the Udmurt language. The graphic and elements of spelling used in the Gospel are based on those of the first Udmurt grammar printed in 1775 under the title âSoà ...
L. M. Ivšin
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source