ð¼ð¾ð» - Open Access .click

Results 111 to 120 of about 8,474,652 (256)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel +2 more
wiley +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source

, 2017
Epidemiological data indicates that thyroid carcinoma (TC) is the most frequent endocrinological tumors, participating with around 1% from all malignomas.
Ð¢Ñ€Ð¸Ð¿ÑƒÐ½Ð¾ÑÐºÐ¸ (Tripunoski), Ð¢Ð¾Ð½Ð¸ (Toni) +3 more
core +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

Perturbations in $$\textbf{O}(D,D)$$ O ( D , D ) string cosmology from double field theory

European Physical Journal C: Particles and Fields
The low-energy limit of string theory contains additional gravitational degrees of freedom, a skew-symmetric tensor B-field and a scalar dilaton, that are not present in general relativity.
Stephen Angus, Shinji Mukohyama
doaj +1 more source

ÐŸÐ ÐžÐ¤Ð•Ð¡Ð˜ÐˆÐ Ð¡Ð˜Ð¡Ð¢Ð•Ðœ ÐÐÐÐ›Ð˜Ð¢Ð˜Ð§ÐÐ [PDF]

, 2016
Ð¸Ð·Ð²Ð°Ð ...
Ð¢Ð¾Ñ‡ÐµÐ²ÑÐºÐ¸, Ð‰ÑƒÐ¿Ñ‡Ð¾
core +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski +2 more
wiley +1 more source

ÐœÐ£Ð›Ð¢Ð˜ÐœÐ•Ð”Ð˜Ð¡ÐšÐ˜ Ð¡Ð˜Ð¡Ð¢Ð•ÐœÐ˜ [PDF]

, 2016
Ð¸Ð·Ð²Ð°Ð ...
Ð¡Ð°Ð»Ð¸Ñƒ, ÐÑ€Ð¼ÐµÐ½Ð´
core +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source

, 2017
Intensification of systemic chemotherapy with incinclusionof high doses methotrexate (MTX) has contributed to the improvement of event-free survival in children with acute lymphoblastic leukemia (ALL). Despite this benefit, this agent might cause serious
Ð§Ð¾Ð½ÐµÑÐºÐ°-ÐˆÐ¾Ð²Ð°Ð½Ð¾Ð²Ð° (Choneska-Jovanova), Ð‘Ð¸Ð»Ñ˜Ð°Ð½Ð° (Biljana) +6 more
core +1 more source

astrophysics
b physics
hadron-hadron scattering experiments