Results 141 to 150 of about 8,794,770 (259)

Причини и поÑледици на повредите на градниот кош во мирновременÑки и воени уÑлови

open access: yes, 2017
We had 107 patients with chest injuries – 95 of them were blunt wounds and 12 were wounds from weapons (rifles, revolvers, shotguns, knives, bayonets ...).Chest injuries are, as serious in the peaceful-time, as in the military conditions. They bring into
Јевтиќ (Jevtikj), Миодраг (Miodrag)   +2 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

СамоубиÑтвата во Скопје и околината во текот на 1979 година

open access: yes, 2017
The aim of our examination was to establish the number of suicides, oldness, sex, professions, calendar and meteorological time, place, manner and means of execution. Our basic duty was to analyse this phenomenon, which number rise slowly, from the year (
ИвановÑки (Ivanovski), Мартин (Martin)   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

ПолициÑтична бубрежна болеÑÑ‚ - приказ на пациент

open access: yes, 2016
Was to present disease, over a patient review of policystic kidney disease, that need hospitalization many times – because of complications that follow it (uroinfection, calculosis, anaemia, chronical kidney insufficiency, hypertension, and cistes crack ...
Миленковиќ (Milenkovikj), Звонко (Zvonko)   +1 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

IBM разви диÑк од 1 GB за преноÑните компјутери

open access: yes, 2016
изваР...
информатика, МЕДИС -
core  

Home - About - Disclaimer - Privacy