Results 61 to 70 of about 9,138,381 (257)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
BMC Pregnancy and ChildbirthBackground Depression, anxiety, and stress are common during the perinatal period and may adversely affect maternal and neonatal outcomes. However, longitudinal data on their trajectories across pregnancy and the postpartum period, as well as their ...
Marija Žonjić +9 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Adiponectin and Leptin—Considerations in Adult Patients with Spinal Muscular Atrophy Type 3
DiagnosticsBackground: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, leading to progressive proximal muscle weakness and paralysis.
Marija Miletić +7 more
doaj +1 more source
To $${d}$$ d , or not to $${d}$$ d : recent developments and comparisons of regularization schemes
European Physical Journal C: Particles and Fields, 2017 We give an introduction to several regularization schemes that deal with ultraviolet and infrared singularities appearing in higher-order computations in quantum field theories.
C. Gnendiger +18 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Lanthanide Hexacyanidoruthenate Frameworks for Multicolor to White-Light Emission Realized by the Combination of d-d, d-f, and f-f Electronic Transitions. [PDF]
Inorg Chem, 2023 Charytanowicz T, Sieklucka B, Chorazy S.
europepmc +1 more source