Results 151 to 160 of about 6,055,275 (250)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Tixutert n tmezgunt deg uselmed/almad n tutlayt n tmaziɣt. Amedya: Asif n tisselbi i d-yettwasuɣlen seg taɛrabt.

open access: yesUssnan
Amagrad-a yewwi-d ɣef txutert n uselmed/almad n tutlayt tmaziɣt s umezgun, amedya tamezgunt n Tawfik El-Hakim yettwasuɣlen ilmend n yidles amaziɣ. Tazrawt-a treṣṣa ɣef yinefkan n tsastant i nga s udiwenni d yiselmaden akked temsirin i neḥḍer deg tneɣrit.
Hassiba Kherbouche, Mohammed Agaoua
doaj  

Assessment of evidence from teeth and the alveolar bone of skulls. [PDF]

open access: yesSci Rep
Mânica S   +3 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy