Results 191 to 200 of about 6,055,275 (250)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Acid-promoted dehydroxylation coupling of aryl alcohols with 1,3-dicarbonyls and sulfonamides. [PDF]

BMC Chem
Liang J, Liu C, Liang Y, Liao J, Luo R, Ouyang L.   +5 more
europepmc   +1 more source

ÐолÑпÑÐ¾Ð²Ð¾Ð´Ð½Ð¸ÐºÐ¾Ð²Ð°Ñ ÑлеменÑÐ½Ð°Ñ Ð±Ð°Ð·Ð° ÑлекÑÑиÑеÑÐºÐ¸Ñ Ð°Ð¿Ð¿Ð°ÑаÑов

, 2017
К. Васерина, А. Сурма, А. Черников, В. Л. Фролов   +3 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Vitellogenin plays a role in regulating honey bee swarming. [PDF]

Sci Rep
Klett K, Ihle KE, Simone-Finstrom M, Spivak M.   +3 more
europepmc   +1 more source

ÐпÑиÑеÑкие ÑвойÑÑва ÑÑÑÑкÑÑÑ AlGaN/GaN/Al2O3 в ÑеÑагеÑÑовом диапазоне ÑаÑÑоÑ

, 2017
Александр Андреевич Артемьев
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Rome IV Diarrhea-Predominant Irritable Bowel Syndrome and Functional Diarrhea Prescribed With Ondansetron: A Real-World Study. [PDF]

Neurogastroenterol Motil
Sbarigia C, Lambiase C, Butt MF, Aliyu AI, Spiller R, Corsetti M.   +5 more
europepmc   +1 more source

ÐÑÑледование заÑÑбежного опÑÑа ÑоÑиалÑной заÑиÑÑ Ð½Ð°ÑелениÑ

, 2016
Татьяна Юрьевна Чернова
openalex   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source