Results 31 to 40 of about 6,055,275 (250)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
N,N-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine monohydrate
IUCrData, 2018 The asymmetric unit of the title compound, C7H9N5·H2O, consists of two formula units differing slightly in the orientation of the dimethylamino groups. In the crystal, a combination of O—H...N and N—H...O hydrogen bonds involving the water molecules of ...
Mohamed El Hafi +5 more
doaj +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
On α′-effects from D-branes in 4d N $$ \mathcal{N} $$ = 1
Journal of High Energy Physics, 2020 In this work we study type IIB Calabi-Yau orientifold compactifications in the presence of space-time filling D7-branes and O7-planes. In particular, we conclude that α′2 g s -corrections to their DBI actions lead to a modification of the four ...
Matthias Weissenbacher
doaj +1 more source
CCT4 promotes tunneling nanotube formation
FEBS Letters, EarlyView.Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto +3 more
wiley +1 more source
Pofessor D. J. van Rooy- 'n waardering
Koers : Bulletin for Christian Scholarship, 1956 So ken ons vir Dirk Jan van Rooy. Deur sy wysheid is hy ’n toring van krag in elke kring waarin hy hom beweeg.
W. P. Robbertse
doaj +1 more source
Forest Gothic of D. N. Mamin-Sibiryak
Филологический класс, 2023 The article analyzes a micro detail of D. N. Mamin-Sibiryak’s landscape poetics: the metaphorical epithet Gothic in descriptions of coniferous forests of the Urals, its semantic role, and genesis.
doaj +1 more source
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
Wilson loops in N $$ \mathcal{N} $$ = 4 SO(N) SYM and D-branes in AdS5 × ℝℙ5
Journal of High Energy Physics, 2021 We study the half-BPS circular Wilson loop in N $$ \mathcal{N} $$ = 4 super Yang-Mills with orthogonal gauge group. By supersymmetric localization, its expectation value can be computed exactly from a matrix integral over the Lie algebra of SO(N).
Simone Giombi, Bendeguz Offertaler
doaj +1 more source