Results 221 to 230 of about 6,151,611 (255)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Gate insulator stack engineering for fully CMOS-compatible reservoir computing. [PDF]

Nano Converg
Hwang J, Park MK, Kim J, Bae JH, Lee JH.
europepmc   +1 more source

ÐоÑвÑд ÑÑÑÑÑгÑÑного лÑкÑÐ²Ð°Ð½Ð½Ñ Ð°Ð´ÐµÐ½Ð¾Ð¼Ð°ÑÐ¾Ð·Ð½Ð¸Ñ Ð¿Ð¾Ð»ÑпÑв пÑÑÐ¼Ð¾Ñ ÐºÐ¸Ñки

, 2015
Олексій Володимирович Новицький, І. М. Шевчук, А. Л. Шаповал   +2 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rotation reversal of chiral bacterial vortices.

Soft Matter
Htet PH, Lauga E.
europepmc   +1 more source

Dissemination of study results to participants in mental health research: a meta-research review of studies published in high-impact psychiatry journals. [PDF]

BMJ Open
Pierson G, Nassar EL, Adams C, Boruff J, Nordlund J, Hu S, Rice DB, Thombs-Vite M, Co N, Cook V, Thombs BD.   +10 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung. [PDF]

Life Sci Alliance
Joy N, Deshpande A, Lingamallu SM, Prabantu VM, Naveenkumar CN, Bharathkumar K, Bhat S, Alvarado-Martinez Z, Livraghi-Butrico A, Hagood JS, Boucher RC, Lafkas D, Byrd KM, Narayanan S, Shandil RK, Guha A.   +15 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

20% Caloric Restriction did not Impact Bone Health nor Exercise-Induced Elevations in Bone Mass in Young Female Rats. [PDF]

Calcif Tissue Int
Sumida KD, Slater B, Folta H, Lee K, Karwande S, Wong Q, Jaque SV, Frisch F.   +7 more
europepmc   +1 more source