Results 111 to 120 of about 6,426,239 (248)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Верификација на квалитативни методи Ñо теÑÑ‚ ленти за иÑпитување на дроги кои Ñе злоупотребуваат во урина

, 2018
The verification of the  qualitative method with test  devices for detection of eight drugs of abuse in urine  (amphetamines, methamphetamine,  barbiturates,  benzoylecgonine,  marijuana, 3,4-methylendioxy-methamphetamine, methadone, and opiates) was ...
ТошеÑка-ТрајковÑка (Tosheska-Trajkovska), Катерина (Katerina), ТопузовÑка (Topuzovska), Соња (Sonja), Лабудовиќ (Labudovik), Даница (Danica), ЦековÑка (Cekovska), Светлана (Svetlana), БогданÑка (Bogdanska), ЈаÑна (Jasna)   +4 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

ЗдравÑтвени ризици при изложеноÑÑ‚ на азбеÑÑ‚ во животната Ñредина - преглед на литературата и ÑоÑтојба во Rепублика Mакедонија

, 2017
International Agency for Research on Cancer (IARC) in 2009 classified all forms of asbestos as sure human carcinogen (Group 1) for lung cancer, mesothelioma of the pleura, and cancer of the larynx and ovary.
Минов (Minov), Јордан (Jordan), КараџинÑка БиÑлимовÑка (Karadzinska Bislimovska), Јованка (Jovanka), РиÑтовÑка (Ristovska), Гордана (Gordana)   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор

, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core  

Razeyev D. N. I. Kant's teleology [PDF]

Кантовский сборник, 2011
Balanovsky, V. V.
doaj   +1 more source