Results 71 to 80 of about 6,056,925 (239)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

ÐзмеÑиÑелÑÐ½Ð°Ñ ÑиÑÑема Ð´Ð»Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° и мониÑоÑинга ÑÑемоÑа

, 2016
Семён Алексеевич Котляров
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

ÐÑÑледование возможноÑÑи ÑÑÐ¸Ð»ÐµÐ½Ð¸Ñ ÑоÑоÑока в геÑеÑоÑÑÑÑкÑÑÑÐ°Ñ II - Ñипа на оÑнове ÑзкозоннÑÑ Ð¿Ð¾Ð»ÑпÑоводников Ð3Ð5

, 2017
Андрей Юрьевич Глотов
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

СиÑÑема пожаÑной Ð¾Ñ ÑÐ°Ð½Ñ Ð¿ÑедпÑиÑÑиÑ

, 2017
Георгий Константинович Яшин
openalex   +1 more source

Улога на тиреоидното ткиво на блаÑÑ‚-транÑфорамцијата на лимфоцитите на болни Ñо тиреотокÑикоза

, 2017
It has been examined the possibility of thyroid tissue as to how as a same antigen influence on blast - transformation, eventually on previously sensitised lymphocytes at thyrotoxicosis patients.The lymphocytes have been separated (taken) from the vein ...
Малинова (Malinova), Љубинка (Ljubinka), КаранфилÑки (Karanfilski), БориÑлав (Borislav)   +1 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

ÐÑоÑеÑÑионалÑÐ½Ð°Ñ Ð¸ ÑизиÑеÑÐºÐ°Ñ Ð¿Ð¾Ð´Ð³Ð¾Ñовка военноÑлÑжаÑÐ¸Ñ Ð¡Ð¨Ð

, 2017
Валерий Александрович Щеголев, Валерий Петрович Сущенко   +1 more
openalex   +1 more source

ИÑпитување на концентрациониот механизам за пертехнетат во тиреоидеата, плунчаните жлезди и желудникот кај Ñтаорец

, 2016
The pertechnetate concentrating mechanism in thyroid gland, salivary glands and stomach was studied in rats by determination tissue: plasma radioactivity ratio.
Радуловиќ (Radulovikj), ВеÑна (Vesna), Серафимов (Serafimov), Ðикола (Nikola), Ðнгелова (Angelova), Г (G)   +2 more
core