Results 81 to 90 of about 332 (162)

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Performance of ginger constituents against SARS-CoV-2 virus: A therapeutic and theoretical approach. [PDF]

Parasite Epidemiol Control
Kadhim MM, Khadom AA, Abaies JK, Kadhum WR, Hachim SK.   +4 more
europepmc   +1 more source

ФинанÑовое ÑоÑÑоÑние пÑедпÑиÑÑÐ¸Ñ ÑоÑговли и оÑенка пеÑÑпекÑив его ÑазвиÑиÑ

, 2017
Надежда Андреевна Шандерова
openalex   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

ЦелеÑообÑазноÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑазной Ñепной ÑеакÑии (PCR) Ñ ÑиÑÑÑгиÑеÑÐºÐ¸Ñ Ð¿Ð°ÑиенÑов Ñ Ð¸Ð½ÑекÑионнÑм ÑндокаÑдиÑом

, 2015
L.А. Maltseva, А.Б. Кутовой, Н Ф Мосенцев   +2 more
openalex   +2 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

Preferential C-nociceptor stimulation facilitates peripheral axon reflex flare, but not secondary mechanical hyperalgesia. [PDF]

Front Pain Res (Lausanne)
Daneffel L, Rukwied R, Schmelz M, Ruppen W, Schneider T.   +4 more
europepmc   +1 more source

ÐногокÑиÑеÑиалÑÐ½Ð°Ñ Ð¾Ð¿ÑимизаÑÐ¸Ñ ÑÑаÑионаÑнÑÑ Ñежимов ÐÐС Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð³ÐµÐ½ÐµÑиÑеÑкого алгоÑиÑма и алгоÑиÑма ÑÐ¾Ñ ÑаÑÑиÑ

, 2016
Александр Чернавин
openalex   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source