Results 131 to 140 of about 6,073,638 (249)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Personalized Surgical Tactics for an Adult Patient with Mitral Insufficiency and Dextrocardia with Situs Inversus Totalis. [PDF]

Braz J Cardiovasc Surg
Kozlov BN, Petlin KA, Lelik EV, Afanasieva NL, Arsenyeva YA, Chernykh YN, Kim EB.   +6 more
europepmc   +1 more source

ÐонÑÑиÑÑÑÐ¸Ñ Ð¸ ÑиÑÑемнÑй кÑÐ¸Ð·Ð¸Ñ Ð² РоÑÑии (каÑаÑелÑÐ½Ð°Ñ Ð¿Ð¾Ð»Ð¸Ñика на ÑÑбеже веков). РазмÑÑÐ»ÐµÐ½Ð¸Ñ Ð½ÐµÑоÑÑоÑвÑегоÑÑ ÑÑаÑÑника ÑобÑÑий

, 2017
Михаил Эмильевич Жаркой
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluating Probe Design for Phylogenomics Across Taxonomic Scales: First Steps for Applying Ultraconserved Elements in an Understudied Class (Mollusca: Polyplacophora). [PDF]

Mol Ecol Resour
Chen Z, Vončina K, Sigwart JD.
europepmc   +1 more source

Ðплив ÑиÑÑÐµÐ¼Ð½Ð¸Ñ ÑмÑÐ½Ð½Ð¸Ñ Ð¿Ð¾ÑÑÑÐµÐ½Ñ Ð½Ð° пеÑебÑг генеÑалÑзованого паÑодонÑиÑÑ Ñ ÑвоÑÐ¸Ñ Ð½Ð° ÑевмаÑоÑдний аÑÑÑиÑ

, 2015
І. П. Мазур, С. І. Сміян, І. І. Білозецький, І. І. Свистун   +3 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Characterizing semi-directed phylogenetic networks and their multi-rootable variants. [PDF]

Theory Biosci
Holtgrefe N, Huber KT, van Iersel L, Jones M, Moulton V.   +4 more
europepmc   +1 more source

ÐРÐÐÐÐÐУÐÐÐÐЯ ÐÐÐÐЬÐÐТÐЧÐÐÐ ÐÐТÐÐÐÐСТРРТÐÐСÐЧÐÐСТРÐÐÐ¥ÐÐÐÐÐ¥ Ñ-ÐÐРÐÐÐСÐÐÐÐТÐÐÐÐÐÐÐÐ fî-ÐÐÐÐÐÐСУÐЬФÐÐÐÐÐÐСÐÐÐÐÐÐÐÐ¥ ÐÐСÐÐТ ÐÐ ÐÐÐÐРÐСТÐÐÐЯРRDF ÐÐÐÐÐУÐЯРÐÐÐ¥ ÐÐСÐРÐÐТÐРÐÐ

, 2014
О. В. Кленіна, В. В. Огурцов, І. Я. Голос, Г. О. Цепелевські, І. П. Банний   +4 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source