Results 161 to 170 of about 5,871,735 (254)

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

Pulsatile sequential drug release system for cascade tumor deep penetration and differentiation therapy to enhance chemoimmunotherapy. [PDF]

Sci Adv
Liu F, Ning S, Wang X, Fan X, Wan B, Sun F, Du L, Shi K, Zou X, Zhu R, Li M, Shen W, He Z, Wang K, Sun J.   +14 more
europepmc   +1 more source

Миграционные ÑвойÑтва нитратов как индикатор Ñ„ÑƒÐ½ÐºÑ†Ð¸Ð¾Ð½Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ñ‡Ð² Ñтепной зоны КазахÑтана

, 2012
T. Ryspekov
openalex  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Outcomes and adverse events following intra-arterial chemotherapy for retinoblastoma: A single center study in South India. [PDF]

World J Clin Pediatr
Das A, Saiteja K, Shah PK, Prema S, Narendran V.   +4 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Biomineralized engineered <i>Lactococcus lactis</i>-based in situ vaccination enhances antitumor immunity via sequential activation of chemo-immunotherapy. [PDF]

J Immunother Cancer
Chen Z, Ke Y, Zhu J, Cen L, Rao W, Hong S, Wang Y, Shao J, Chu Y, Qian X, Liu B, Li R, Liu Q.   +12 more
europepmc   +1 more source

Ð”ÐµÐ³Ð¸Ð´Ñ€Ð°Ñ‚Ð°Ñ†Ð¸Ñ Ð±Ð¸Ð¾Ñтанола в Ñтилен на окÑидных катализаторах

, 2013
К. Dossumov, Dina Churina, Ðœ. Telbayeva, K. Kalikhanov   +3 more
openalex   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Association of a healthy lifestyle with mortality risk among individuals with osteoarthritis: a prospective cohort study of the UK Biobank. [PDF]

BMJ Open
Wang N, Lu N, Zhang J, Lu C, Sha T, Wang H.   +5 more
europepmc   +1 more source