Results 71 to 80 of about 5,638,500 (213)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Effects of Antiepileptic Drugs, Carbamazepine and Phenytoin, on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in Japanese Patients With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Ikawa K, Imura T, Nakamura S, Murata K, Morikawa N, Sakata M, Yasuzawa H, Horikawa N.   +7 more
europepmc   +1 more source

ÐŸÐµÑ€Ñ Ð¿ÐµÐºÑ‚Ð¸Ð²Ð¸ и проблеми на обучението по приложна етика в Ð£Ð½Ð¸Ð²ÐµÑ€Ñ Ð¸Ñ‚ÐµÑ‚Ð° за национално и Ñ Ð²ÐµÑ‚Ð¾Ð²Ð½Ð¾ Ñ Ñ‚Ð¾Ð¿Ð°Ð½Ñ Ñ‚Ð²Ð¾ [PDF]

, 2020
ВаРÐμÐ ⁄ Ñ‚Ð ̧Ð ⁄ а ДраР⁄ аРР̧ÐμРа
openalex  

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. [PDF]

Sci Rep
Alshahawy RZ, Safwat SM, El-Kholy SS, El-Basiony SF, El-Desouky S, Helmi SM.   +5 more
europepmc   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Optimization of MALDI Matrices and Their Preparation for the MALDI-TOF MS Analysis of Oligonucleotides. [PDF]

Rapid Commun Mass Spectrom
Dietrich S, Dollinger A, Wieser A, Haisch C.   +3 more
europepmc   +1 more source

Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]

, 2020
Ð Ð ⁄ Ñ‚Ð ⁄ Ð ⁄ ГÐμруР⁄ Ð ⁄ Ð
openalex  

Correction: Differential associations of somatic and cognitive-affective symptoms of depression with inflammation and insulin resistance: cross-sectional and longitudinal results from the Emotional Distress Sub-Study of the GRADE study. [PDF]

Diabetologia
Ehrmann D, Krause-Steinrauf H, Uschner D, Wen H, Hoogendoorn CJ, Crespo-Ramos G, Presley C, Arends VL, Cohen RM, Garvey WT, Martens T, Willis HJ, Cherrington A, Gonzalez JS, GRADE Research Group.   +14 more
europepmc   +1 more source