Results 51 to 60 of about 6,247,202 (205)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

(E)-N′-{7-Methoxyspiro[chromeno[4,3-d]thiazole-4,1′-cyclohexan]-2-yl}-N,N-dimethylacetimidamide

Acta Crystallographica Section E, 2011
In the chromenothiazole ring system of the title molecule, C20H25N3O2S, the pyran ring is in a half-chair conformation. The dihedral angle between the thiazole and benzene rings is 14.78 (6)°.
Kamini Kapoor, Vivek K. Gupta, Rajni Kant, Poorvesh M. Vyas, Mihir J. Joshi, Kalpesh M. Menpara, Kartik D. Ladva   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Little strings on D n orbifolds

Journal of High Energy Physics, 2017
We explore two classes of 6d N = 1 0 $$ \mathcal{N}=\left(1,0\right) $$ little string theories obtained from type IIA/IIB NS5-branes probing D n singularities.
Joonho Kim, Kimyeong Lee
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Dynamical symmetry enhancement near N $$ \mathcal{N} $$ = 2, D = 4 gauged supergravity horizons

Journal of High Energy Physics, 2017
We show that all smooth Killing horizons with compact horizon sections of 4-dimensional gauged N $$ \mathcal{N} $$ = 2 supergravity coupled to any number of vector multiplets preserve 2 c 1 K + 4 ℓ $$ 2{c}_1\left(\mathcal{K}\right)+4\ell ...
J. Gutowski, T. Mohaupt, G. Papadopoulos
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

On (n,D)- quasi Operators

Iraqi Journal for Computer Science and Mathematics
T Through the article, we will provide an entirely novel type of quasi operators base on the concept of D razin inverse in Operator theory which is named (n,D) -quasi operators on the Hilbert spaces, also we explain the sum, product, and other features ...
salim dawood mohsen
doaj   +1 more source