Results 221 to 230 of about 6,172,849 (234)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Effect of exercise on hormonal responses in adolescents with obesity and leptin resistance: a randomized trial. [PDF]

Sci Rep
Jeong D, Valentine RJ, Park K, Jeong H, Hong J, Kang S.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders. [PDF]

Addict Biol
Pavirani L, Seelarbokus BA, Marinelli L, Desnavailles P, Berthoz S, Fatseas M.   +5 more
europepmc   +1 more source

Serum 25-Hydroxyvitamin D Levels in Breast Cancer Patients: A Cross-Sectional Analysis by Molecular Tumor Subtypes. [PDF]

J Clin Med
Weber D, Stanisławek A, Irzmańska-Hudziak A, Kulik T, Pacian AB, Baryła-Matejczuk M, Łuczyk M, Łuczyk R.   +7 more
europepmc   +1 more source

Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system. [PDF]

Proc Natl Acad Sci U S A
Matsui S, Takahashi Y, Morioka S, Ozawa T, Kanayama S, Iwama H, Geng L, Umemoto K, Oguri Y, Tsuzuki S, Li Y, Hikida T, Sasaki T.   +12 more
europepmc   +1 more source

Effect of calcium and vitamin D supplementation on recurrence of benign paroxysmal positional vertigo in osteoporotic patients. [PDF]

Am J Transl Res
Wang Z, He G, Chen Z, Jie H, Zeng Q.
europepmc   +1 more source

Bicuspid Aortic Valve: Old and Novel Gene Contribution to Disease Onset and Complications. [PDF]

Diagnostics (Basel)
Sticchi E, De Cario R, Suraci S, Kura A, Berteotti M, Squillantini L, Barbieri G, Orsi R, Fugazzaro MP, Colonna S, Gensini F, Fiorentini E, Gori AM, Marcucci R, Pepe G, Nistri S, Giusti B.   +16 more
europepmc   +1 more source