Results 81 to 90 of about 6,270,424 (234)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Degree sequence for k-arc strongly connected multiple digraphs

open access: yesJournal of Inequalities and Applications, 2017
Let D be a digraph on { v 1 , … , v n } $\{v_{1},\ldots, v_{n}\}$ . Then the sequence { ( d + ( v 1 ) , d − ( v 1 ) ) , … , ( d + ( v n ) , d − ( v n ) ) } $\{ (d^{+}(v_{1}), d^{-}(v_{1})), \ldots, (d^{+}(v_{n}), d^{-}(v_{n}))\}$ is called the degree ...
Yanmei Hong, Qinghai Liu
doaj   +1 more source

N $$ \mathcal{N} $$ -extended D = 4 supergravity, unconventional SUSY and graphene

open access: yesJournal of High Energy Physics, 2020
We derive a 2+1 dimensional model with unconventional supersymmetry at the boundary of an AdS4 N $$ \mathcal{N} $$ -extended supergravity, generalizing previous results. The (unconventional) extended supersymmetry of the boundary model is instrumental in
L. Andrianopoli   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Tagelda n Kuku d tqerrabin d lǧerrat tinmettiyin i d-teǧǧa

open access: yesRevue d'Histoire Méditerranéenne
Deg umagrad-a, nemmeslay-d ɣef yiwet n tgelda i yesɛan azal meqqren deg umezruy atrar n Lezzayer s umata ladɣa amezruy n tmurt n Leqbayel, tagi d tageda n Kuku i d-ibanen deg useggas 1511, seld tuṭṭfa n temdint n Bgayet s ɣur Spenyul deg useggas 1510 ...
BENCHIKHE Ali
doaj  

Распределение d(n,ω) в классах вычетов [PDF]

open access: yesПроблемы анализа, 1995
В работе устанавливаются условия слабо равномерного распределения значений функции d(n,ω) с вещественным характером Дирихле ω(n) в классах вычетов по составному модулю и приводятся асимптотические формулы.
Широков Б. М.
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stark Widths Regularities Within: ns-np, np-ns, np-nd, nd-np and nd-nf Spectral Series of Potassium Isoelectronic Sequence

open access: yesAtoms, 2019
Results presented in this paper show a regular behaviour of Stark widths within the studied spectral series of potassium isoelectronic sequence. These regularities have been found and verified on the basis of the existing theoretical and experimental ...
Nora Trklja   +3 more
doaj   +1 more source

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