Results 61 to 70 of about 5,871,736 (254)

6-Azido-3-O-benzyl-6-deoxy-N,N-diethyl-1,2-O-isopropylidene-d-glycero-α-d-gluco-heptofuranuronamide

Acta Crystallographica Section E, 2011
Reaction of 3-O-benzyl-1,2-O-isopropylidene-α-xylo-pentodialdo-1,4-furanose with N,N-diethyl-2-(dimethylsulfuranilidene)acetamide gave stereoselectively an epoxyamide, which was regioselectively opened by NaN3 in dimethyl formamide to give the ...
M. S. Pino-González, A. L. Thompson, G. W. J. Fleet, A. Romero, N. Oña, S. F. Jenkinson   +5 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Crystal structure of 4,4′-(4,10-diphenyl-4,10-dihydropyreno[4,5-d:9,10-d′]diimidazole-5,11-diyl)bis(N,N-diphenylaniline), C66H44N6

Zeitschrift für Kristallographie - New Crystal Structures, 2018
C66H44N6, triclinic, P1̄ (no. 2), a = 9.773(2) Å, b = 14.406(3) Å, c = 18.385(4) Å, α = 72.64(3)°, β = 82.10(3)°, γ = 76.90(3)°, V = 2399.5(8) Å3, Z = 2, Rgt(F) = 0.0546, wRref(F2) = 0.1559, T = 153(2) K.
Liu Yulong, Dong Zhaojia, Guo Youquan, Fu Ying   +3 more
doaj   +1 more source

Загадочное зырянское слово абутор ’медведь-самец в пору течки’ [A Mysterious Komi Zyrian Word: абутор ’male bear in heat’] [PDF]

Linguistica Uralica
The paper investigates the Russian dialectal word абутор ’male bear in heat’ and its later fixation абуторь ’walking (not hibernating) bear’. The author proposes to discuss its new interpretation.
Galina Fedyuneva
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

ЭКОНОМИЧЕСКИЕ РЫЧАГИ МУНИЦИПАЛЬНОЙ ПОЛИТИКИ В СФЕРЕ ОХРАНЫ АТМОСФЕРНОГО ВОЗДУХА НА ПРИМЕРЕ ГОРОДА ЛЬВОВА

Mokslo Taikomieji Tyrimai Lietuvos Kolegijose, 2019
Проаналізовано екологічний стан атмосферного повітря у м. Львові. Визначено основні проблеми, що спричиняють надмірне забруднення повітр
Галина Нестеренко
doaj  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

МЕНЕДЖМЕНТ КУЛЬТУРЫ В МАЛОМ БИЗНЕСЕ РЕСПУБЛИКИ МОЛДОВА

Mokslo Taikomieji Tyrimai Lietuvos Kolegijose, 2016
организационная культура выполняет важную роль в формировании инновационного поведения сотрудников.
Екатерина Барбарош
doaj