Results 191 to 200 of about 6,180,758 (249)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Assessment of vitamin D nutritional status among adults in Lu'an, China, based on serum 25-hydroxyvitamin D measured by LC-MS/MS. [PDF]

Front Nutr
Liu C, Zhan X, Qin B, Sun L, Zhai R.
europepmc   +1 more source

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, 2013
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openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

РезÑлÑÑаÑи повÑоÑÐ½Ð¸Ñ Ð½ÐµÐ¹ÑоÑÑÑÑÑгÑÑÐ½Ð¸Ñ Ð²ÑÑÑÑÐ°Ð½Ñ Ð¿Ñи ÑÑÐ°Ð²Ð¼Ñ Ð¿ÐµÑиÑеÑиÑÐ½Ð¸Ñ Ð½ÐµÑвÑв нижнÑÑ ÐºÑнÑÑвок.

, 2013
В. І. Цимбалюк, М. М. Татарчук   +1 more
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. [PDF]

EBioMedicine
Stewart I, Jacob J, Porter JC, Liu B, Tatler AL, Gomez N, Pugh MR, John AE, Allen RJ, Blaikley JF, Chaudhuri N, Denneny E, Fabbri L, George PM, Guillen-Guio B, Gooptu B, Hall IP, Ho LP, Jarrold I, Johnson S, Jones MG, Khan F, Mehta P, Mitchell J, Molyneaux PL, Pearl JE, Piper Hanley K, Platé M, Quinn V, Rivera-Ortega P, Saunders LC, Smith DJF, Spears M, Spencer LG, Stanel SC, Thompson AAR, Walsh S, Wild JM, Wootton DG, Docherty AB, Gleeson F, Greenhalf W, Harrison EM, Lone N, Quint J, Maslova A, Pohl M, Stephens A, Young S, Singapuri A, Shikotra A, Sereno M, Saunders RM, Richardson M, Raman B, Poinasamy K, McAuley HJC, Marks M, Leavy OC, Houchen-Wolloff L, Horsley A, Harris VC, Greening N, Evans RA, Elneima O, Chalmers JD, Brightling CE, Chambers RC, Wain LV, Jenkins RG, PHOSP-COVID Collaborative Group and the UKILD Consortium.   +70 more
europepmc   +1 more source

РазÑабоÑка безопаÑной инÑоÑмаÑионной ÑиÑÑÐµÐ¼Ñ Ð´Ð»Ñ ÑпÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð³Ð¾ÑÑдаÑÑÑвеннÑм мÑзеем "ÐÑмиÑаж"

, 2016
Виктория Шупик
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source