Results 81 to 90 of about 6,180,758 (249)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

ÐÑминеÑÑенÑÐ½Ð°Ñ ÑпекÑÑоÑÐºÐ¾Ð¿Ð¸Ñ ÑглеÑоднÑÑ Ð½Ð°Ð½Ð¾ÑоÑек

, 2017
Марк Даниилович Любаров
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

СÑÑÐ°Ñ Ð¾Ð²Ð°Ð½Ð¸Ðµ междÑнаÑоднÑÑ Ð°Ð²ÑомобилÑнÑÑ Ð¿ÐµÑевозок гÑÑзов

, 2016
Дмитрий Александрович Белов
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tisekta d twuriwin n yismawen imaẓlayen deg yimahilen iseklanen : asaka n tezlatin n Ǧamal Ɛellam

Ussnan
In this article, which explores the use of proper names in Djamel Allam's songs, we will examine this lexical category that lies between two essential domains: linguistics and literature.
Atmane RAHMANI
doaj  

ÐзмеÑиÑелÑÐ½Ð°Ñ ÑиÑÑема Ð´Ð»Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° и мониÑоÑинга ÑÑемоÑа

, 2016
Семён Алексеевич Котляров
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Ðнализ ÑинанÑового ÑоÑÑоÑÐ½Ð¸Ñ Ð¿ÑедпÑиÑÑÐ¸Ñ Ð¸ оÑенка пеÑÑпекÑив его ÑазвиÑиÑ

, 2016
София Алексеевна Лобода
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source