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Results 81 to 90 of about 6,270,495 (248)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

N. A. Polevojaus laiškai S. D. Poltorackiui

Literatūra (Vilnius), 1966
Nikolajus Aleksejevičius Polevojus (1796–1846), žinomas „Maskvos telegrafo" redaktorius ir leidėjas, vienas iš žymesniųjų V. G. Belinskio pirmtakų, rusų XIX a. literatūroje buvo antidvarininkiškos literatūros kritikos pradininkas. Jis pradėjo
V. Salinka
doaj +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source

, 2017
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
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core +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source

Measurement of D0, D+, D*+ and D s + production in Pb-Pb collisions at s N N = 5.02 $$ \sqrt{{\mathrm{s}}_{\mathrm{NN}}}=5.02 $$ TeV

Journal of High Energy Physics, 2018
We report measurements of the production of prompt D0, D+, D*+ and D s + mesons in Pb–Pb collisions at the centre-of-mass energy per nucleon-nucleon pair s N N = 5.02 $$ \sqrt{s_{\mathrm{NN}}}=5.02 $$ TeV, in the centrality classes 0–10%, 30–50% and 60 ...
The ALICE collaboration +1003 more
doaj +1 more source

, 2017
The aim of this study was to determinate the importance of 6MWT in children diagnosed with neuromuscular diseases. We evaluated the distances walked and the level of fatigue manifested.
Sabolik, Vesna +8 more
core +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source

supersymmetric gauge theory
extended supersymmetry
astrophysics

crystal structure
supergravity models