Results 111 to 120 of about 6,309,199 (255)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Tisekta d twuriwin n yismawen imaẓlayen deg yimahilen iseklanen : asaka n tezlatin n Ǧamal Ɛellam
UssnanIn this article, which explores the use of proper names in Djamel Allam's songs, we will examine this lexical category that lies between two essential domains: linguistics and literature.
Atmane RAHMANI
doaj
ПРИСТÐП ДО БЕЗБЕДÐРВОДРЗРПИЕЊЕ ВО СЕВЕРОИСТОЧÐИОТ РЕГИОРÐРРЕПУБЛИКРМÐКЕДОÐИЈÐ- РЕТРОСПЕКТИВÐÐ ÐÐÐЛИЗР[PDF]
, 2017 СeвероиÑточниот Регион на Република Македонија, Ñо површина од 2310 км2, го Ñочинуваат опш- тините Куманово, Старо Ðагоричино, Кратово, Ранковце,
КочубовÑки, Михаил +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
UssnanAmagrad-a yewwi-d ɣef txutert n uselmed/almad n tutlayt tmaziɣt s umezgun, amedya tamezgunt n Tawfik El-Hakim yettwasuɣlen ilmend n yidles amaziɣ. Tazrawt-a treṣṣa ɣef yinefkan n tsastant i nga s udiwenni d yiselmaden akked temsirin i neḥḍer deg tneɣrit.
Hassiba Kherbouche, Mohammed Agaoua
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Feedback between US and UK Prices: a Frequency Domain Analysis [PDF]
This paper decomposes the feedback between US and UK price levels by frequency over the period 1791 to 1990. By adapting Geweke's (1982) method of decomposing the feedback between time series to the case of I(1) time series generated by a bivariate error-
Jahyeong Koo, Paul A. Johnson
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source