Results 151 to 160 of about 6,270,976 (255)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tagelda n Kuku d tqerrabin d lǧerrat tinmettiyin i d-teǧǧa

Revue d'Histoire Méditerranéenne
Deg umagrad-a, nemmeslay-d ɣef yiwet n tgelda i yesɛan azal meqqren deg umezruy atrar n Lezzayer s umata ladɣa amezruy n tmurt n Leqbayel, tagi d tageda n Kuku i d-ibanen deg useggas 1511, seld tuṭṭfa n temdint n Bgayet s ɣur Spenyul deg useggas 1510 ...
BENCHIKHE Ali
doaj  

Technical Characteristics and Biomedical Applications of Flexible Pressure Sensor Matrices: A Scoping Review. [PDF]

Sensors (Basel)
Cimignolo S, Fruet D, Nollo G, Masè M.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Timuzzla deg tmurt n Leqbayel (Lezzayer), gar umezruy d tgemmi: taddart n Yiḥiṭṭuṣen

Langues & Cultures
Tazrawt-nneɣ tekcem di taɣult n tesnalest tadelsant, yes-s nezrew agraw anmetti n Yiḥiṭṭusen d yiḥeddaden-is s wayes-s i neɛreḍ ad d-nessegzi belli tanḍa d tmuzzla d yiwen n uneḍru anmetti amatu.
Massinissa SAIDANI
doaj  

Preoperative Beta-Hydroxy-Beta-Methyl-Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice. [PDF]

Acta Physiol (Oxf)
Vieira-da-Silva AL, Esteca MV, Silva FA, Divino IA, Carneiro FS, Ropelle ER, Torsoni AS, Baptista IL.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach. [PDF]

Basic Clin Pharmacol Toxicol
Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Optimization of systemic AAV9 gene therapy in Niemann-Pick disease, type C1 mice. [PDF]

Life Sci Alliance
Mylvara AV, Gibson AL, Gu T, Davidson CD, Incao AA, Melnyk K, Gembic SR, Pierre-Jacques D, Cologna SM, Venditti CP, Porter FD, Pavan WJ.   +11 more
europepmc   +1 more source